Endocrine Abstracts

Background: Diets rich in polyunsaturated fatty acids (PUFA) n-3 may change the fluidity and composition of membrane phospholipids, leading to different prostanoids formation, decreasing IL-1β and TNFα releases and increasing the basal levels of corticosterone, important factors to promote acute phase response (APR) to stimuli. This study proposes to verify if PUFA n-3 or n-6 rich diets alters the APR of fibrinogen and haptoglobin after turpentine stimulus.<p cla...

Cushing’s syndrome (CS) is a severe disease caused by an endogenous glucocorticoid excess and it is correlated to an increased morbidity and mortality especially for sepsis and cardiovascular diseases, while hypertension, glucose intolerance or diabetes mellitus, and dyslipidemia are the most common systemic complications. The aim of this retrospective study was to evaluate the mortality and morbidity of patients with CS admitted at the Department of Endocrinology and Onc...

Cabergoline (CAB) was demonstrated to be effective in normalizing cortisol secretion in a subset of patients with Cushing’s disease (CD). The aim of the study was to evaluate the impact of chronic treatment with CAB on clinical, metabolic and hormonal parameters in CD patients. Twenty-six patients with CD (11 males, 15 females, 12–72 years) entered the study. Patients were divided into two groups, responders and non responders, according to the achievement or not of ...

Women with acromegaly present often menstrual irregularity, anovularity and infertility. A direct role of GH and IGF1 excess on the hypothalamus–pituitary–gonadal axis, hyperprolactinemia and an impaired gonadotrophin secretion related to a tumor mass effect, or polycystic ovary syndrome have been suggested as possible mechanisms related to infertility. However, no systematic data are available on fertility in these patients. The aim of this retrospective study was t...

Deficiency of 17β-hydroxysteroid dehydrogenase type 3 (17βHSD3), an enzyme converting androstenedione (A) to testosterone (T) in the Leydig cells of the testis, is a rare cause of autosomal recessive 46,XY disorders of sexual development (DSD). A 18-year-old phenotypically female patient presented with primary amenorrhea. She had deep voice, macrocephaly, broad forehead, enlarged nasal tip, macrostomia, facial acne, gynecomastia, left-convex dorsal scoliosis, hypopla...